Bupropion

Bupropion is a prescription antidepressant that affects dopamine and norepinephrine, two brain chemicals involved in mood. It is used for depression, and certain products help people quit smoking. Results vary. A licensed physician in your state reviews your health history to decide whether bupropion is appropriate for you.

Bupropion does not work right away for depression. It may take several weeks or longer to feel its full benefit. Results vary. Take it as prescribed and keep follow-up visits. Contact your physician if symptoms worsen, side effects interfere with daily life, or you have concerns about your progress.

Certain bupropion products are prescribed to help adults quit smoking by reducing cravings and withdrawal symptoms. Results vary. The medicine does not contain nicotine. A licensed physician in your state decides whether it is appropriate and explains when to start, how to take it, and how to plan your quit date.

Bupropion is generally less likely than SSRIs to cause sexual side effects, such as lower desire or trouble reaching orgasm. Results vary. Sexual side effects can still happen, and depression itself can affect sexual health. Discuss concerns with your physician rather than changing or stopping your medicine on your own.

Bupropion is generally less likely than many SSRIs to cause weight gain, and some people lose weight while taking it. Results vary. Weight gain can still occur. Bupropion alone is not FDA-approved for weight management, and your physician should review any large or unexpected change in weight or appetite.

Bupropion should not be used by people with a seizure disorder or a current or past diagnosis of anorexia nervosa or bulimia. Certain medicines and sudden withdrawal from alcohol or sedatives can also make it unsafe. A licensed physician in your state must review your history before deciding whether treatment is appropriate.

Bupropion can cause dry mouth, nausea, constipation, headache, trouble sleeping, or feeling restless. Serious risks include seizures, high blood pressure, and major mood changes. Seek emergency care for a seizure or severe allergic reaction. If you are in emotional crisis, call or text 988, the Suicide & Crisis Lifeline.

Bupropion can interact with prescription drugs, over-the-counter medicines, supplements, and alcohol. Do not combine it with another bupropion product. Alcohol can raise safety concerns, including seizure risk. Give your physician and pharmacist a complete list of what you take, and ask before starting, stopping, or changing any medicine or drinking habits.

Take bupropion exactly as prescribed because the schedule depends on its release form. Do not crush, chew, or split sustained-release or extended-release tablets. If you miss a dose, skip it and take the next dose at the usual time. Never double a dose, since extra bupropion increases seizure risk.

Talk with your physician before stopping bupropion or switching antidepressants. The plan depends on your dose, release form, symptoms, and other medicines. Your physician may recommend a gradual dose change. Depression can return after treatment stops. Results vary. Do not overlap medicines or change your schedule without clear medical instructions.