Medications · FAQ
Can I stop bupropion or switch to another antidepressant?
Short answer
Talk with your physician before stopping bupropion or switching antidepressants. The plan depends on your dose, release form, symptoms, and other medicines. Your physician may recommend a gradual dose change. Depression can return after treatment stops. Results vary. Do not overlap medicines or change your schedule without clear medical instructions.
Do not stop bupropion or switch antidepressants without a plan from your physician. They will consider why you want to stop, how long you have taken it, your dose, and your current symptoms. A dose reduction may be recommended, depending on your treatment and the product you use.
Feeling better does not always mean it is time to stop. Continuing treatment may help lower the chance of depression returning. Results vary. Your physician can discuss how long treatment makes sense based on your history and any past episodes of depression.
Switching medicines needs careful timing. Some drugs may be started during a planned transition, while others require a gap. MAOIs need a specific waiting period. Do not use leftover medicine or overlap prescriptions unless your physician tells you to do so.
Arrange follow-up during and after the change. Report worsening mood, major sleep changes, or troubling side effects promptly. If you are in emotional crisis or thinking about suicide, call or text 988, the Suicide & Crisis Lifeline. Call 911 for immediate danger.
Sources
Written by the Verra clinical team · Medical review pending
General information, not medical advice. If you're in crisis, call or text 988.