Medications · FAQ
Can I take bupropion with other medicines or alcohol?
Short answer
Bupropion can interact with prescription drugs, over-the-counter medicines, supplements, and alcohol. Do not combine it with another bupropion product. Alcohol can raise safety concerns, including seizure risk. Give your physician and pharmacist a complete list of what you take, and ask before starting, stopping, or changing any medicine or drinking habits.
Bupropion can interact with many medicines. It can change the levels of certain antidepressants, antipsychotics, and heart medicines. Some drugs, including tramadol and other medicines that lower the seizure threshold, may increase seizure risk when combined with it. Your physician and pharmacist should check your full medication list.
Do not take more than one product containing bupropion. This includes products prescribed for depression, smoking cessation, or weight management. Different product names can hide the same active ingredient. Ask your pharmacist if you are unsure.
MAOIs require special precautions and a waiting period when switching. Also tell your physician about antibiotics such as linezolid, nicotine replacement, stimulants, supplements, and nonprescription products. Do not assume a product is safe because it does not need a prescription.
Discuss alcohol use honestly. It is best to avoid alcohol while taking bupropion unless your physician advises otherwise. If you drink heavily or regularly, do not suddenly stop without medical advice. Alcohol withdrawal can raise seizure risk and may need supervised care.
Sources
Written by the Verra clinical team · Medical review pending
General information, not medical advice. If you're in crisis, call or text 988.