Licensed physicians in all 50 states · Free, discreet shipping · Compounded in a US-licensed pharmacy

Medication

Tadalafil

Written by the Verra clinical team · Medical review pending · Last updated Oct 4, 2026

Quick answer

Tadalafil is a PDE5 inhibitor used for erectile dysfunction, either daily at a low dose or as needed. It is the active ingredient in Cialis and lasts up to 36 hours. It must not be combined with nitrates.

Key takeaways

  • Long-lasting: up to 36 hours.
  • Daily low dose allows spontaneity.
  • Also used for enlarged prostate symptoms.

What it is

An oral PDE5 inhibitor.

How it works

It improves blood flow with arousal, similar to sildenafil but longer acting.

Forms and doses we offer

Daily low-dose tablets and a combination chew.

Common side effects

Headache, indigestion, back or muscle aches, flushing and congestion.

Who should not take it

People on nitrates, with recent heart events, severe low blood pressure or certain eye conditions.

Interactions to discuss

Nitrates, alpha-blockers, strong CYP3A4 inhibitors and alcohol.

Verra treatments containing tadalafil

A licensed provider decides whether a treatment is appropriate after your visit.

Questions

What is tadalafil, and how does it treat erectile dysfunction?

Tadalafil is a prescription medicine that helps increase blood flow to the penis during sexual arousal. It belongs to a group called PDE5 inhibitors and is the active ingredient in Cialis. It does not cause an automatic erection or increase sexual desire. Results vary.

How long does tadalafil take to work, and what does up to 36 hours mean?

As-needed tadalafil is usually taken at least 30 minutes before sex, and it may support erections for up to 36 hours. Results vary. This is a window when the medicine may help during sexual arousal, not a prediction that an erection will last that long.

How is daily tadalafil different from as-needed tadalafil?

Daily tadalafil uses a lower dose taken around the same time each day. As-needed tadalafil is taken before planned sex, following your prescription. Either approach may help with erections during sexual arousal. Results vary. A licensed physician in your state decides which schedule is appropriate for you.

How should I take tadalafil, and what if I miss a daily dose?

Take tadalafil exactly as prescribed, with or without food. For daily treatment, take it around the same time each day. If you miss a daily dose, take it when you remember unless it is almost time for the next dose. Never double up or exceed your prescribed schedule.

Why must tadalafil never be combined with nitrates or poppers?

Tadalafil must not be combined with nitrates or recreational nitrites, often called poppers, because the combination can cause a dangerous drop in blood pressure. If you have chest pain after taking tadalafil, call 911. Do not take nitroglycerin yourself, and tell emergency staff when you last took tadalafil.

Which medicines and supplements can interact with tadalafil?

Tadalafil can interact with nitrates, riociguat, alpha blockers, blood pressure medicines, and some antibiotics, antifungals, and HIV medicines. Do not combine it with another ED medicine unless your prescriber directs you to. Share all prescriptions, over-the-counter medicines, supplements, and recreational drugs before starting tadalafil or adding a new treatment.

What side effects can tadalafil cause, and which need urgent care?

Tadalafil can cause headache, indigestion, flushing, a stuffy nose, back pain, or muscle aches. Seek emergency care for an erection lasting more than four hours, chest pain, or a severe allergic reaction. Stop tadalafil and seek urgent medical care for sudden vision loss or a sudden decrease or loss of hearing.

Who needs extra medical review before taking tadalafil for ED?

Tadalafil needs careful review if you have heart disease, blood pressure problems, kidney or liver disease, or certain eye, hearing, or blood conditions. People taking nitrates or riociguat must not use it. A licensed physician in your state decides whether tadalafil and sexual activity are appropriate for your health.

Can I drink alcohol or eat normally while taking tadalafil?

You can take tadalafil with or without food, but heavy drinking can raise the risk of dizziness, headache, and low blood pressure. Alcohol can also make erections harder to achieve. Results vary. Ask your prescriber about alcohol use, and check with your pharmacist before eating grapefruit or drinking grapefruit juice.

What should I do if tadalafil is not helping or I want to stop or switch?

Contact your prescriber if tadalafil is not helping, causes side effects, or no longer fits your needs. Results vary. Do not increase the dose, add another ED medicine, or switch on your own. Tadalafil for ED usually does not need tapering, but discuss your plan with your prescriber.

Related reading

Not sure what fits? Take the treatment finder

Sources

This page is general information, not medical advice. Results vary. Compounded medications are not FDA-approved. Our editorial policy

Your visit pays for itself.

Five minutes online. A physician reviews it within 24 hours, and your $99 visit fee is credited in full toward your first order.

Start your visit

Verra letters

Plain-English health guides, about once a month.

New treatments, honest answers and notes on member pricing. Unsubscribe anytime.