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Medication

Sertraline

Written by the Verra clinical team · Medical review pending · Last updated Oct 4, 2026

In crisis? Call or text 988 (Suicide & Crisis Lifeline) any time, or call 911 for an emergency.

Quick answer

Sertraline is an SSRI antidepressant used for depression, anxiety disorders, panic and OCD. It typically takes 4 to 6 weeks for full effect. Antidepressants carry a warning about suicidal thoughts in young people. In crisis, call or text 988.

Key takeaways

  • First-line for depression and many anxiety disorders.
  • Full effect takes several weeks.
  • Do not stop suddenly.

What it is

A selective serotonin reuptake inhibitor.

How it works

It increases serotonin activity in the brain.

Forms and doses we offer

Tablets prescribed through our mental health program.

Common side effects

Nausea, diarrhea, sleep changes, sweating and sexual side effects.

Who should not take it

People taking MAOIs or pimozide.

Interactions to discuss

Other serotonergic drugs (risk of serotonin syndrome), blood thinners and NSAIDs.

Verra treatments containing sertraline

A licensed provider decides whether a treatment is appropriate after your visit.

Questions

What is sertraline used to treat?

Sertraline is a prescription antidepressant used for depression, panic disorder, OCD, and some other anxiety-related conditions. It belongs to a group called SSRIs. A licensed physician in your state decides whether it fits your symptoms and health history. It may help reduce symptoms over time. Results vary.

How does sertraline work?

Sertraline changes how the brain handles serotonin, a chemical involved in mood and other body functions. It blocks serotonin from being taken back up as quickly by nerve cells. These changes may help ease depression or anxiety symptoms with ongoing treatment. Results vary, and the benefit is not immediate.

How long does sertraline take to work?

Sertraline often takes about 4 to 6 weeks for a clear benefit, and full benefit can take longer, especially for OCD. Results vary. Some changes may appear sooner than others. Keep taking it as prescribed and discuss progress with your physician rather than changing the dose yourself.

How should I take sertraline, and what if I miss a dose?

Take sertraline exactly as prescribed, usually once daily at a consistent time. Your physician chooses the dose and any changes. If you miss a dose, take it when remembered unless it is almost time for the next one. Skip it then, and never double doses to catch up.

What common side effects can sertraline cause?

Sertraline can cause nausea, diarrhea, sweating, shaking, sleep changes, and sexual side effects. Some early effects may ease as your body adjusts. Results vary. Tell your physician about symptoms that are severe, last, or affect daily life. Do not stop or change your dose without medical guidance.

Does sertraline carry a warning about suicidal thoughts?

Yes. Sertraline carries an antidepressant warning about an increased risk of suicidal thoughts and behavior in children, teens, and young adults, especially early in treatment or after dose changes. People of any age need monitoring. If you are in crisis, call or text 988. Call 911 for immediate danger.

Which medicines, supplements, or drinks can interact with sertraline?

Sertraline can interact with other antidepressants, certain pain and migraine medicines, blood thinners, and supplements such as St. John's wort. Some combinations can be dangerous. Avoid alcohol, and give your physician and pharmacist a full list of everything you take before starting sertraline or adding another product.

Who needs extra medical review before taking sertraline?

Sertraline needs extra review if you have bipolar disorder, seizures, liver disease, bleeding problems, glaucoma, or a history of low sodium. Pregnancy and breastfeeding also need a risk-benefit discussion. A licensed physician in your state reviews your health history and medicines to decide whether sertraline is appropriate.

Which sertraline side effects need urgent medical attention?

Get urgent help for trouble breathing, swelling of the face or throat, seizures, serious bleeding, or confusion with fever and stiff muscles while taking sertraline. These may signal a serious reaction. New suicidal thoughts also need prompt attention. Call 911 for immediate danger or 988 for a mental health crisis.

Can I stop sertraline or switch to another antidepressant?

Do not stop sertraline suddenly or switch antidepressants on your own. Stopping too quickly can cause withdrawal symptoms, and your original symptoms may return. Your physician can plan a gradual dose reduction or a safe switch based on your treatment history, current dose, side effects, and other medicines.

Related reading

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Sources

This page is general information, not medical advice. Results vary. Compounded medications are not FDA-approved. Our editorial policy

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