Medications · FAQ
How does sertraline work?
Short answer
Sertraline changes how the brain handles serotonin, a chemical involved in mood and other body functions. It blocks serotonin from being taken back up as quickly by nerve cells. These changes may help ease depression or anxiety symptoms with ongoing treatment. Results vary, and the benefit is not immediate.
Sertraline belongs to a group of medicines called selective serotonin reuptake inhibitors, or SSRIs. It slows the reuptake of serotonin, which means nerve cells do not take this chemical back up as quickly. This changes serotonin signaling in the brain. Depression and anxiety are complex conditions, not simply a matter of having too little serotonin.
The medicine starts affecting serotonin signaling before you may notice changes in your symptoms. Over time, treatment may help with low mood, fear, panic, or unwanted thoughts. Results vary. It does not work like a sedative, and it is not meant to stop a panic attack right away.
Serotonin also plays a role outside the brain. This helps explain why sertraline can cause effects such as nausea, diarrhea, or sexual problems.
Take sertraline only as prescribed. A licensed physician in your state decides whether it fits your needs and checks how you respond. Do not raise the dose or add other serotonin-affecting medicines or supplements on your own.
Sources
Written by the Verra clinical team · Medical review pending
General information, not medical advice. If you're in crisis, call or text 988.