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How do SSRIs work for depression?

Short answer

SSRIs are antidepressants that change how the brain uses serotonin, a chemical involved in mood and other functions. They can reduce depression symptoms over time. Results vary. A licensed physician in your state reviews your health history, other medicines, and possible risks before deciding whether an SSRI is appropriate.

SSRIs stands for selective serotonin reuptake inhibitors. These medicines slow the reabsorption of serotonin between nerve cells. Serotonin helps carry signals involved in mood and other body functions. Depression is complex, and it is not simply caused by a lack of serotonin. The full reasons antidepressants work are still being studied.

SSRIs are commonly used for depression. They may ease symptoms over several weeks rather than right after a dose. Results vary. Different SSRIs have different dosing instructions and interactions. Your physician considers your symptoms, past treatment, other health conditions, and personal preferences when discussing an option.

Possible side effects include nausea, headache, sleep changes, and sexual problems. Tell your physician about all prescription medicines, over-the-counter products, and supplements you take. Also mention any history of bipolar disorder or unusually high energy with little need for sleep. Do not change your dose or stop on your own. Ask your physician what follow-up is needed and which symptoms need urgent attention.

Sources

Written by the Verra clinical team · Medical review pending

General information, not medical advice. If you're in crisis, call or text 988.

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