Medications · FAQ
Which medicines and supplements interact with spironolactone?
Short answer
Spironolactone can interact with potassium supplements, potassium-based salt substitutes, some blood pressure medicines, and certain pain relievers. Other important interactions include trimethoprim and lithium. Share every prescription, over-the-counter medicine, and supplement with your physician and pharmacist. Do not stop a prescribed medicine on your own.
Several medicines can raise potassium when taken with spironolactone. Examples include ACE inhibitors, ARBs, other potassium-sparing diuretics, and the antibiotic trimethoprim. Some combinations are used under medical supervision, but they may require closer lab monitoring. Never assume that a medicine is safe to combine because it treats a different condition.
Nonsteroidal anti-inflammatory drugs, or NSAIDs, such as ibuprofen and naproxen, can affect kidney function and interact with spironolactone. Lithium also needs careful review. Birth control that contains drospirenone can add to potassium concerns. Ask your clinician or pharmacist before starting a new prescription or an over-the-counter pain medicine.
Include vitamins, herbs, electrolyte powders, and workout supplements in your medication list. Potassium supplements and potassium-based salt substitutes are especially important to flag. Alcohol can worsen dizziness or lightheadedness. Do not stop needed medicines or make major diet changes without guidance. Your physician can decide whether a combination should be avoided, adjusted, or monitored based on your full health history.
Sources
Written by the Verra clinical team · Medical review pending
General information, not medical advice. If you're in crisis, call or text 988.