How does spironolactone treat acne and unwanted hair from polycystic ovary syndrome (PCOS)?

Spironolactone is a prescription medicine that blocks some androgen effects. A physician may prescribe it off-label for acne or unwanted facial and body hair linked to PCOS. Off-label means the medicine is being used for a purpose outside its FDA-approved labeling. It is not a treatment for every part of PCOS.

Skin and hair changes happen slowly. Spironolactone may reduce new hair growth, but it does not remove existing hair. Results vary. Hair removal methods may still be useful. Your physician will explain when to review progress rather than increasing the dose on your own.

Possible side effects include more frequent urination, dizziness, breast tenderness, and irregular bleeding. It can also raise potassium levels. Kidney disease, potassium supplements, some blood pressure medicines, and other drugs can increase this risk. Blood tests may be needed based on your health and medication history.

Spironolactone should not be used during pregnancy because of possible effects on fetal development. If pregnancy is possible, discuss reliable contraception. Tell your physician right away if you become pregnant or plan to try. A licensed physician in your state decides whether this medicine is appropriate.