Can pilocarpine treat dry mouth (xerostomia), and how does it work?

Pilocarpine stimulates receptors that signal certain glands to release fluid, including saliva. Oral pilocarpine is used for dry mouth related to Sjogren's syndrome and reduced saliva after radiation treatment to the head and neck. It may not be suitable for every cause of dryness, and results vary.

Your clinician will review the likely cause, your symptoms, and your medical history before prescribing. The amount of working saliva gland tissue can affect the response. Pilocarpine does not rebuild damaged glands or cure an underlying immune system condition. It also does not replace brushing, fluoride, or dental visits.

Take it only as prescribed. The dose and timing depend on your situation and how well you tolerate it. Do not take extra doses to try to get faster relief. Ask your pharmacist what to do if you miss a dose. A licensed physician or dentist in your state decides whether treatment is appropriate. Follow-up is important to review any benefit, sweating or other side effects, and ongoing dental needs.