Comparisons · FAQ
Can I switch between sildenafil and tadalafil or take them together?
Short answer
Do not combine sildenafil and tadalafil or switch between them without your prescriber’s guidance. Their effects can overlap, raising the risk of low blood pressure and other side effects. A safe switch depends on your last dose, kidney and liver health, other medicines, and the treatment schedule you use.
Sildenafil and tadalafil act on the same pathway. Taking them together can increase side effects, including headache, dizziness, low blood pressure, and a prolonged erection. Do not add one because the other did not seem to work or because you want a longer treatment window.
Switching may be an option if timing, side effects, or your response makes the current medicine a poor fit. Results vary. A licensed physician in your state decides whether a switch is appropriate and gives you instructions for stopping one medicine and starting the other.
There is no single waiting rule that is right for every patient. Tadalafil remains in the body longer than sildenafil. Daily tadalafil also creates ongoing exposure. Kidney or liver problems and interacting medicines can change how long either drug stays in your system.
Tell your prescriber the exact product, dose, and time you last took it. If you accidentally take both, seek prompt medical advice before taking any more. Call 911 for fainting or chest pain, and seek emergency care for an erection lasting longer than 4 hours.
Sources
Written by the Verra clinical team · Medical review pending
General information, not medical advice. If you're in crisis, call or text 988.
Related guides
Related questions
- What is the main difference between sildenafil and tadalafil for erectile dysfunction?
- How quickly do sildenafil and tadalafil start working?
- Does tadalafil last longer than sildenafil, and what does that mean?
- Can sildenafil and tadalafil both be taken every day for erectile dysfunction?
- Is sildenafil or tadalafil more effective for erectile dysfunction?