Are oral medications an option for premature ejaculation (PE)?

Some oral medicines are used off-label for premature ejaculation. Off-label use means a medicine is prescribed for a purpose outside its FDA-approved uses. Certain antidepressants, including some selective serotonin reuptake inhibitors, may delay ejaculation. Results vary. This does not mean a person taking them for PE has depression.

Potential side effects include nausea, sleep changes, sweating, and changes in sexual desire or erections. Some medicines can interact with antidepressants, pain medicines, migraine treatments, or supplements. Tell your physician about everything you take, as well as any history of bipolar disorder or major mood changes.

The dosing schedule depends on the exact medicine and your needs. Do not borrow medication, change your dose, or stop a daily antidepressant suddenly without medical guidance. Ask your physician which options are available and appropriate rather than assuming any particular medicine will be prescribed. Report new or worsening mood symptoms promptly. Anyone in crisis can call or text 988, the Suicide & Crisis Lifeline. Call 911 for immediate danger.