Which medicines or supplements can interact with nitrofurantoin UTI treatment?

Before starting nitrofurantoin, share every medicine and supplement you take with your physician and pharmacist. Include prescription drugs, vitamins, herbal products, antacids, and over-the-counter bladder symptom products. Include medicines you take only occasionally, not just daily prescriptions. This helps your care team check for interactions before you start treatment.

Antacids containing magnesium trisilicate can reduce nitrofurantoin absorption. Probenecid and sulfinpyrazone, which are used for gout, can change how your kidneys handle nitrofurantoin. These interactions may affect safety or how well treatment works. Results vary. Do not assume that spacing medicines a few hours apart will prevent an interaction; ask your pharmacist for specific advice.

Tell your physician if you are taking another antibiotic or plan to receive an oral typhoid vaccine. Do not stop a regular medicine, add a new product, or combine antibiotics on your own. Kidney function also affects whether nitrofurantoin is appropriate. Your physician will review both your medication list and health history before deciding on treatment. This list does not cover every possible interaction.