What side effects can Topical Spironolactone + Minoxidil cause?

Possible side effects include itching, redness, dryness, flaking, and burning where you apply the medication. The ingredients used to make the solution may also cause irritation or an allergic reaction. Unwanted hair may grow outside the treatment area if medication spreads onto nearby skin. Results vary.

Some people notice increased shedding early in minoxidil treatment. Results vary. Do not assume that new or severe hair loss is harmless. Tell your physician if shedding is heavy, lasts longer than expected, or comes with pain or scalp changes.

Stop using the medication and seek prompt medical care for chest pain, fainting, a fast heartbeat, sudden weight gain, or swelling of your hands or feet. Call 911 for trouble breathing or swelling of your face, lips, or tongue.

Safety data for this exact topical combination are limited. Compounded medications are prepared by a licensed pharmacy for one patient and are not FDA-approved. Tell your physician about heart or kidney disease, low blood pressure, pregnancy, plans for pregnancy, or breastfeeding before treatment.