Finasteride vs dutasteride: What mood changes and other safety concerns should I discuss?

Your physician needs a full health history before prescribing either medicine. Share any history of depression, thoughts of self-harm, liver disease, or drug allergies. Mood changes, including depression and suicidal thoughts, have been reported with finasteride. Do not assume that dutasteride is a risk-free substitute if you have mood concerns.

Contact your prescriber promptly if you develop new or worsening depression or unusual mood changes. Anyone in crisis can call or text 988, the Suicide & Crisis Lifeline. Call 911 if there is immediate danger or a medical emergency.

Both medicines can lower PSA, a blood marker used in prostate care. Tell any clinician ordering a PSA test that you take finasteride or dutasteride. A lower reading needs to be interpreted with your treatment history in mind.

Also share all prescription drugs, over-the-counter medicines, and supplements. Dutasteride can interact with some medicines that affect how the liver breaks it down. Seek urgent care for trouble breathing or swelling of the lips, tongue, or throat, which may signal a serious allergic reaction.